Widening the windows into individuality

Introducing Opus 23: A new genomic analysis software program developed by Dr. Peter D’Adamo

What is Opus23?

Opus23 is a software program that interprets raw genomic data from 23andme, a service company that performs genomic analysis and reports their findings back to you. At the Center of Excellence (COE), we then take the raw data from 23andme and run it through Opus23. Opus23 then ‘translates’ the raw genetic data into clinically relevant and important information that the COE staff physicians can then use to institute preventive or therapeutic actions.

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What’s the process?

If a COE staff member recommends that you consider doing a ‘nutrigenomic consult’ they will ask you to contact 23andme to purchase a test kit. Their Ancestry kit costs $99 USD and is available directly from www.23andme.com. When you receive the test kit, you will have to collect a saliva sample, fill out the forms, and then mail it back.

In about 3 weeks, you will receive an email that your results are ready. You then log in to 23andme, download the results as a raw data ‘ZIP’ file and email it to the COE at least one week before you come in for the nutrigenomic consult. Alternately (with your permission and login details), we can download it for you.

Once we have the raw data, we then can load it into Opus23 and begin our analysis.

How does it work?

23andme reports over 700,000 individual genetic markers called SNPs (pronounced ‘snips’). SNP stands for ‘single nucleotide polymorphism.’ which simply indicates that at some point in the genome there was a variation in one of the letters of DNA (A,T,C,G) from what was normally to be expected. For example, a person might have a SNP with a ‘C’ at that location, whereas a ‘T’ would normally be expected. SNPs are very common, as each of us are uniquely different genetically from each other. Many SNPs have been associated with certain risks (such as diseases or susceptibilities).

Opus23 combs through the results and looks for these special SNPs. It then activates it own analytic machinery and reports back to the physician any areas of special interest. This type of testing would have cost tens of thousands of dollars as little as a few years ago; the fact that it’s available at such a reasonable cost is a testimony to the amazing developments in modern technology.

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Opus23 takes raw genomic data and using an incredible array of software tools,
converts it into medically relevant information .

What is the COE nutrigenomic consult?

When a COE clinician suggests running Opus23, you will be asked to schedule a nutrigenomic consult. This is a 60-minute visit where the clinicians will analyze the Opus report data and relay its results back to you. Any specific recommendations regarding lifestyle changes, nutritional therapies, supplements or other naturopathic therapies will be discussed at that time.

In keeping with the spirit of the role of the COE as a teaching institution, and reflecting the fact that Opus23 was developed in-house, the cost of the nutrigenomic consult is available. Many institutions and clinics charge as much as ten times this amount for genetic consultations using software far less powerful than Opus23. Your investment in Opus23 and the COE nutrigenomic consult will continue to grow with time. New functions are constantly being added to Opus23. With each new release of Opus23, your COE clinicians will continue to run your data through each new version.

Opus23 Checklist (for COE patients only):

  • COE clinician recommends Opus23 and a COE nutrigenomic consult
  • Schedule the COE nutrigenomic consult at least 8 weeks in advance with the front desk
  • Purchase a 23andme test kit from www.23andme.com (Ancestry kit $99 USD)
  • Carefully follow all the instructions when the kit arrives, collect a saliva sample, fill out all forms, and return to 23andme ASAP
  • Provide raw data to COE when notification is received that your 23andme test results are ready
  • Download the raw data file and email it to the address we’ve provided to you
  • Supply us with the login data and we will download it for you
  • Show up for your scheduled nutrigenomic consult for the Opus23 analysis results

Opus23 was conceived and programmed by Dr. Peter D’Adamo, Distinguished Professor of Clinical Sciences at the University of Bridgeport, and Director of the Center of Excellence in Generative Medicine. However, he had lots of help. Over twenty naturopathic physicians and students actively curate the various Opus23 databases, constantly updating them as new information is reported. Opus23 Pro was designed with one simple goal: to allow the physician to make the most information-rich judgments possible.